Targeting SARM1 improves autophagic stress-induced axonal neuropathy.

ABSTRACT

ABBREVIATIONS AAV adeno-associated virus; ATF3 activating transcription factor 3; ATG7 autophagy related 7; AVIL advillin; cADPR cyclic ADP ribose; CALC calcitonin/calcitonin-related polypeptide; CMT Charcot-Marie-Tooth disease; cKO conditional knockout; DEG differentially expressed gene; DRG dorsal root ganglion; FE-SEM field emission scanning electron microscopy; IF immunofluorescence; NCV nerve conduction velocity; PVALB parvalbumin; RAG regeneration-associated gene; ROS reactive oxygen species; SARM1 sterile alpha and HEAT/Armadillo motif containing 1; SYN1 synapsin I.