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Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes.
Sankhala, Rajeshwer S; Dussupt, Vincent; Donofrio, Gina; Gromowski, Gregory D; De La Barrera, Rafael A; Larocca, Rafael A; Mendez-Rivera, Letzibeth; Lee, Anna; Choe, Misook; Zaky, Weam; Mantus, Grace; Jensen, Jaime L; Chen, Wei-Hung; Gohain, Neelakshi; Bai, Hongjun; McCracken, Michael K; Mason, Rosemarie D; Leggat, David; Slike, Bonnie M; Tran, Ursula; Jian, Ningbo; Abbink, Peter; Peterson, Rebecca; Mendes, Erica Araujo; Freitas de Oliveira Franca, Rafael; Calvet, Guilherme Amaral; Bispo de Filippis, Ana Maria; McDermott, Adrian; Roederer, Mario; Hernandez, Mayda; Albertus, Amie; Davidson, Edgar; Doranz, Benjamin J; Rolland, Morgane; Robb, Merlin L; Lynch, Rebecca M; Barouch, Dan H; Jarman, Richard G; Thomas, Stephen J; Modjarrad, Kayvon; Michael, Nelson L; Krebs, Shelly J; Joyce, M Gordon.
Afiliação
  • Sankhala RS; Emerging Infectious Disease Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
  • Dussupt V; Emerging Infectious Disease Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910
  • Donofrio G; Emerging Infectious Disease Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910
  • Gromowski GD; Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • De La Barrera RA; Pilot Bioproduction Facility, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Larocca RA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Mendez-Rivera L; Emerging Infectious Disease Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910
  • Lee A; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Choe M; Emerging Infectious Disease Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
  • Zaky W; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Mantus G; George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
  • Jensen JL; Emerging Infectious Disease Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
  • Chen WH; Emerging Infectious Disease Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
  • Gohain N; Emerging Infectious Disease Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
  • Bai H; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • McCracken MK; Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Mason RD; Vaccine Research Center, NIH, Bethesda, MD 20852, USA.
  • Leggat D; Vaccine Research Center, NIH, Bethesda, MD 20852, USA.
  • Slike BM; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Tran U; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Jian N; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Abbink P; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Peterson R; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Mendes EA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Freitas de Oliveira Franca R; Oswaldo Cruz Foundation Institute Aggeu Magalhães, Recife, PE 50740-465, Brazil.
  • Calvet GA; Oswaldo Cruz Foundation, Evandro Chagas National Institute of Infectious Diseases, Rio de Janeiro, RJ 21040-360, Brazil.
  • Bispo de Filippis AM; Oswaldo Cruz Foundation, Oswaldo Cruz Institute, Rio de Janeiro, RJ 21041-300, Brazil.
  • McDermott A; Vaccine Research Center, NIH, Bethesda, MD 20852, USA.
  • Roederer M; Vaccine Research Center, NIH, Bethesda, MD 20852, USA.
  • Hernandez M; Integral Molecular, Philadelphia, PA 19104, USA.
  • Albertus A; Integral Molecular, Philadelphia, PA 19104, USA.
  • Davidson E; Integral Molecular, Philadelphia, PA 19104, USA.
  • Doranz BJ; Integral Molecular, Philadelphia, PA 19104, USA.
  • Rolland M; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Robb ML; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
  • Lynch RM; George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
  • Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Jarman RG; Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Thomas SJ; Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Modjarrad K; Emerging Infectious Disease Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Michael NL; Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Krebs SJ; Emerging Infectious Disease Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910
  • Joyce MG; Emerging Infectious Disease Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910
Cell Rep ; 42(8): 112942, 2023 08 29.
Article em En | MEDLINE | ID: mdl-37561630
ABSTRACT
Zika virus (ZIKV) is an emerging pathogen that causes devastating congenital defects. The overlapping epidemiology and immunologic cross-reactivity between ZIKV and dengue virus (DENV) pose complex challenges to vaccine design, given the potential for antibody-dependent enhancement of disease. Therefore, classification of ZIKV-specific antibody targets is of notable value. From a ZIKV-infected rhesus macaque, we identify ZIKV-reactive B cells and isolate potent neutralizing monoclonal antibodies (mAbs) with no cross-reactivity to DENV. We group these mAbs into four distinct antigenic groups targeting ZIKV-specific cross-protomer epitopes on the envelope glycoprotein. Co-crystal structures of representative mAbs in complex with ZIKV envelope glycoprotein reveal envelope-dimer epitope and unique dimer-dimer epitope targeting. All four specificities are serologically identified in convalescent humans following ZIKV infection, and representative mAbs from all four groups protect against ZIKV replication in mice. These results provide key insights into ZIKV-specific antigenicity and have implications for ZIKV vaccine, diagnostic, and therapeutic development.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas Virais / Dengue / Vírus da Dengue / Zika virus / Infecção por Zika virus Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas Virais / Dengue / Vírus da Dengue / Zika virus / Infecção por Zika virus Idioma: En Ano de publicação: 2023 Tipo de documento: Article