Identification of 5-HT2 Serotonin Receptor Modulators through the Synthesis of a Diverse, Tropane- and Quinuclidine-alkaloid-Inspired Compound Library.

Yao, Ruwei; Jensen, Anders A; Bryce-Rogers, Hogan P; Schultz-Knudsen, Katrine; Zhou, Libin; Hovendal, Nicklas P; Pedersen, Henrik; Kubus, Mariusz; Ulven, Trond; Laraia, Luca

Yao, Ruwei; Jensen, Anders A; Bryce-Rogers, Hogan P; Schultz-Knudsen, Katrine; Zhou, Libin; Hovendal, Nicklas P; Pedersen, Henrik; Kubus, Mariusz; Ulven, Trond; Laraia, Luca.

Afiliação

Yao R; Department of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800 Kgs Lyngby, Denmark.
Jensen AA; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Bryce-Rogers HP; Department of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800 Kgs Lyngby, Denmark.
Schultz-Knudsen K; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Zhou L; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Hovendal NP; Department of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800 Kgs Lyngby, Denmark.
Pedersen H; Medicinal Chemistry, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark.
Kubus M; Department of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800 Kgs Lyngby, Denmark.
Ulven T; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Laraia L; Department of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800 Kgs Lyngby, Denmark.

J Med Chem ; 66(16): 11536-11554, 2023 08 24.

Article em En | MEDLINE | ID: mdl-37566000

Assuntos

Alcaloides; Quinuclidinas; Serotonina; Alcaloides/farmacologia; Receptor 5-HT2A de Serotonina; Receptor 5-HT2C de Serotonina; Receptores de Serotonina; Agonistas do Receptor 5-HT2 de Serotonina/farmacologia; Antagonistas do Receptor 5-HT2 de Serotonina/farmacologia; Tropanos; Quinuclidinas/química; Quinuclidinas/farmacologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinuclidinas / Serotonina / Alcaloides Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinuclidinas / Serotonina / Alcaloides Idioma: En Ano de publicação: 2023 Tipo de documento: Article