Metabolic and oxidative stress response of sea cucumber Apostichopus japonicus exposed to acute high concentration of bisphenol AF.
Aquat Toxicol
; 262: 106654, 2023 Sep.
Article
em En
| MEDLINE
| ID: mdl-37579560
ABSTRACT
Bisphenols are known as endocrine disruptor that affect the development, and growth of marine creatures, including human. There were plenty of manuscripts evaluated the toxicology of bisphenol A (BPA) and its analogues such as bisphenol F (BPF), bisphenol AF (BPAF), and bisphenol S (BPS), but limits of them studied the effects of bisphenol analogues on echinoderms. In this study, we used metabolomics to investigate the metabolic response of sea cucumber (Apostichopus japonicus) exposed to BPAF, and the activities of glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) were determined. The results demonstrated alterations in lipid metabolism, glycerophospholipid metabolism, and biosynthesis of amino acids following BPAF treatment. Sea cucumbers upregulated the glycerophospholipid metabolism to repair the destruction of intestine cellular homeostasis. Six metabolites were selected as the potential biomarkers for the exposure of BPAF. This study revealed the metabolic response and oxidative response of sea cucumber arising from BPAF exposure, and provided theoretical support for the risk assessment of bisphenol analogues on economically important echinoderms, such as A. japonicus.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pepinos-do-Mar
/
Poluentes Químicos da Água
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Stichopus
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article