Your browser doesn't support javascript.
loading
Association between vmPFC gray matter volume and smoking initiation in adolescents.
Xiang, Shitong; Jia, Tianye; Xie, Chao; Cheng, Wei; Chaarani, Bader; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Büchel, Christian; Desrivières, Sylvane; Flor, Herta; Grigis, Antoine; Gowland, Penny A; Brühl, Rüdiger; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Poustka, Luise; Hohmann, Sarah; Fröhner, Juliane H; Smolka, Michael N; Vaidya, Nilakshi; Walter, Henrik; Whelan, Robert; Garavan, Hugh; Schumann, Gunter; Sahakian, Barbara J; Robbins, Trevor W; Feng, Jianfeng.
Afiliação
  • Xiang S; Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, China.
  • Jia T; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China.
  • Xie C; Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, China. tianyejia@fudan.edu.cn.
  • Cheng W; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China. tianyejia@fudan.edu.cn.
  • Chaarani B; Centre for Population Neuroscience and Stratified Medicine (PONS Centre), ISTBI, Fudan University, Shanghai, China. tianyejia@fudan.edu.cn.
  • Banaschewski T; Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. tianyejia@fudan.edu.cn.
  • Barker GJ; Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, China.
  • Bokde ALW; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China.
  • Büchel C; Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, China.
  • Desrivières S; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China.
  • Flor H; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
  • Grigis A; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Gowland PA; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Brühl R; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
  • Martinot JL; University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
  • Martinot MP; Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Nees F; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Orfanos DP; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
  • Poustka L; NeuroSpin, C.E.A., Université Paris-Saclay, Gif-sur-Yvette, France.
  • Hohmann S; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, Nottingham, UK.
  • Fröhner JH; Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany.
  • Smolka MN; Institut National de la Santé et de la Recherche Médicale, INSERM U1299 'Trajectoires développementales en psychiatrie', Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS UMR9010, Centre Borelli, Gif-sur-Yvette, France.
  • Vaidya N; Institut National de la Santé et de la Recherche Médicale, INSERM U1299 'Trajectoires développementales en psychiatrie', Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS UMR9010, Centre Borelli, Gif-sur-Yvette, France.
  • Walter H; AP-HP, Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France.
  • Whelan R; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Garavan H; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Schumann G; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, Germany.
  • Sahakian BJ; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
  • Robbins TW; Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.
  • Feng J; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Nat Commun ; 14(1): 4684, 2023 08 15.
Article em En | MEDLINE | ID: mdl-37582920
ABSTRACT
Smoking of cigarettes among young adolescents is a pressing public health issue. However, the neural mechanisms underlying smoking initiation and sustenance during adolescence, especially the potential causal interactions between altered brain development and smoking behaviour, remain elusive. Here, using large longitudinal adolescence imaging genetic cohorts, we identify associations between left ventromedial prefrontal cortex (vmPFC) gray matter volume (GMV) and subsequent self-reported smoking initiation, and between right vmPFC GMV and the maintenance of smoking behaviour. Rule-breaking behaviour mediates the association between smaller left vmPFC GMV and smoking behaviour based on longitudinal cross-lagged analysis and Mendelian randomisation. In contrast, smoking behaviour associated longitudinal covariation of right vmPFC GMV and sensation seeking (especially hedonic experience) highlights a potential reward-based mechanism for sustaining addictive behaviour. Taken together, our findings reveal vmPFC GMV as a possible biomarker for the early stages of nicotine addiction, with implications for its prevention and treatment.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tabagismo / Substância Cinzenta Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tabagismo / Substância Cinzenta Idioma: En Ano de publicação: 2023 Tipo de documento: Article