Multi-targeting liposomal codelivery of cisplatin and rapamycin inhibits pancreatic cancer growth and metastasis through stromal modulation.

Zhu, Wenting; Yu, Hang; Jia, Menglei; Lin, Caiyan; Yuan, Zhongwen; Tan, Xiaoxiao; Yan, Pengke

Zhu, Wenting; Yu, Hang; Jia, Menglei; Lin, Caiyan; Yuan, Zhongwen; Tan, Xiaoxiao; Yan, Pengke.

Afiliação

Zhu W; Department of Pharmacy, Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China.
Yu H; Department of Pharmacy, Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China.
Jia M; Department of Pharmacy, Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China.
Lin C; Department of Pharmacy, Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China.
Yuan Z; Department of Pharmacy, Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China.
Tan X; Department of Pharmacy, Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China.
Yan P; Department of Pharmacy, Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China. Electr

Int J Pharm ; 644: 123316, 2023 Sep 25.

Article em En | MEDLINE | ID: mdl-37586573

Assuntos

Neoplasias Hepáticas; Neoplasias Pancreáticas; Animais; Camundongos; Cisplatino/farmacologia; Lipossomos; Sirolimo/farmacologia; Lipopolissacarídeos; Neoplasias Pancreáticas/tratamento farmacológico; Neoplasias Pancreáticas/patologia; Peptídeos/uso terapêutico; Neoplasias Hepáticas/tratamento farmacológico; Linhagem Celular Tumoral; Neoplasias Pancreáticas

Palavras-chave

ATF24 peptide; Cisplatin; Co-delivery; Liposomes; Liver metastasis; Pancreatic cancer; Rapamycin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Neoplasias Hepáticas Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Neoplasias Hepáticas Idioma: En Ano de publicação: 2023 Tipo de documento: Article