A highly antigenic fragment within the zoonotic Cryptosporidium parvum Gp900 glycoprotein (Domain 3) is absent in human restricted Cryptosporidium species.
PLoS One
; 18(8): e0287997, 2023.
Article
em En
| MEDLINE
| ID: mdl-37590269
ABSTRACT
We identified a fragment (Domain 3-D3) of the immunodominant sporozoite surface glycoprotein of the zoonotic parasite Cryptosporidium gp900, which is absent C. hominis and C. parvum anthroponosum. The fragment is highly antigenic and is able to effectively differentiate between zoonotic C. parvum and species/genotypes that infect preferentially humans. D3 detection provides a serological tool to determine whether the source of human cryptosporidiosis is of animal or human origin. We demonstrate this in experimentally challenged piglets, mice, rats, and alpaca. We speculate that the absence of this fragment from the C. hominis and C. parvum anthroponosum gp900 protein may play a key role in their host restriction.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Camelídeos Americanos
/
Cryptosporidium parvum
/
Criptosporidiose
/
Cryptosporidium
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article