Antitumor effect of trimetazidine in a model of solid Ehrlich carcinoma is mediated by inhibition of glycolytic pathway and AKT signaling.

Hazem, Reem M; Aboslema, Rasha F; Mehanna, Eman T; Kishk, Safaa M; Elsayed, Mohammed; El-Sayed, Norhan M

Hazem, Reem M; Aboslema, Rasha F; Mehanna, Eman T; Kishk, Safaa M; Elsayed, Mohammed; El-Sayed, Norhan M.

Afiliação

Hazem RM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.
Aboslema RF; The Egyptian Ministry of Health and Population, Port Said, Egypt.
Mehanna ET; Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt. Electronic address: eman.taha@pharm.suez.edu.eg.
Kishk SM; Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.
Elsayed M; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.
El-Sayed NM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.

Chem Biol Interact ; 383: 110672, 2023 Sep 25.

Article em En | MEDLINE | ID: mdl-37591408

Assuntos

Carcinoma; Trimetazidina; Animais; Camundongos; Proteínas Proto-Oncogênicas c-akt; Trimetazidina/farmacologia; Trimetazidina/uso terapêutico; Simulação de Acoplamento Molecular; Proteína Supressora de Tumor p53

Palavras-chave

AKT; Fatty acid oxidation; Glucose oxidation; Trimetazidine; c-Myc; p53

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Trimetazidina / Carcinoma Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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XML

PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Trimetazidina / Carcinoma Idioma: En Ano de publicação: 2023 Tipo de documento: Article