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IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis.
An, Cheng; Sun, Fei; Liu, Can; Huang, Shaojun; Xu, Tao; Zhang, Chengxin; Ge, Shenglin.
Afiliação
  • An C; Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
  • Sun F; Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
  • Liu C; Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
  • Huang S; Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
  • Xu T; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, China.
  • Zhang C; Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China. Electronic address: zhangchengxin@ahmu.edu.cn.
  • Ge S; Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China. Electronic address: geshenglin@ahmu.edu.cn.
Int Immunopharmacol ; 123: 110795, 2023 Oct.
Article em En | MEDLINE | ID: mdl-37597406
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Aterosclerose Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Aterosclerose Idioma: En Ano de publicação: 2023 Tipo de documento: Article