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HTLV-1 cell-free DNA in plasma as a potential biomarker in HTLV-1 carriers and adult T-cell leukemia-lymphoma.
Katsuya, Hiroo; Nakamura, Hideaki; Maeda, Aya; Ishii, Keitaro; Nagaie, Toshiaki; Sano, Haruhiko; Sano, Haruna; Itamura, Hidekazu; Okamoto, Sho; Ando, Toshihiko; Watanabe, Toshiki; Uchimaru, Kaoru; Satou, Yorifumi; Sueoka, Eisaburo; Kimura, Shinya.
Afiliação
  • Katsuya H; Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan.
  • Nakamura H; Department of Transfusion Medicine Saga University Hospital Saga Japan.
  • Maeda A; Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan.
  • Ishii K; Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan.
  • Nagaie T; Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan.
  • Sano H; Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan.
  • Sano H; Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan.
  • Itamura H; Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan.
  • Okamoto S; Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan.
  • Ando T; Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan.
  • Watanabe T; Department of Practical Management of Medical Information Graduate School of Medicine St. Marianna University Kawasaki Japan.
  • Uchimaru K; Laboratories of Tumor Cell Biology Department of Computational Biology and Medical Sciences Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan.
  • Satou Y; Division of Genomics and Transcriptomics Joint Research Center for Human Retrovirus Infection Kumamoto University Kumamoto Japan.
  • Sueoka E; Department of Clinical Laboratory Medicine Faculty of Medicine Saga University Saga Japan.
  • Kimura S; Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan.
EJHaem ; 4(3): 733-737, 2023 Aug.
Article em En | MEDLINE | ID: mdl-37601876
ABSTRACT
Viral cell-free DNA (cfDNA) in plasma has been widely evaluated for detecting cancer and monitoring disease in virus-associated tumors. We investigated whether the amount of cfDNA of human T-cell leukemia virus type 1 (HTLV-1) correlates with disease state in adult T-cell leukemia-lymphoma (ATL). HTLV-1 cfDNA in aggressive ATL was significantly higher than that in indolent ATL and asymptomatic carriers. Notably, patients with lymphoma type represented higher HTLV-1 cfDNA amount than chronic and smoldering subtypes, though they had no abnormal lymphocytes in the peripheral blood. HTLV-1 cfDNA can be a universal biomarker that reflects the expansion of ATL clones.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article