Ferrostatin-1 Blunts Right Ventricular Hypertrophy and Dysfunction in Pulmonary Arterial Hypertension by Suppressing the HMOX1/GSH Signaling.

Song, Jiawei; Chen, Yihang; Chen, Yufei; Wang, Siyuan; Dong, Zhaojie; Liu, Xinming; Li, Xueting; Zhang, Zhenzhou; Sun, Lanlan; Zhong, Jiuchang

Song, Jiawei; Chen, Yihang; Chen, Yufei; Wang, Siyuan; Dong, Zhaojie; Liu, Xinming; Li, Xueting; Zhang, Zhenzhou; Sun, Lanlan; Zhong, Jiuchang.

Afiliação

Song J; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Institute of Respiratory Medicine and Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Chen Y; Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Chen Y; Medical Research Center, Beijing Institute of Respiratory Medicine and Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Wang S; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Institute of Respiratory Medicine and Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Dong Z; Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Liu X; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Institute of Respiratory Medicine and Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Li X; Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Zhang Z; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Institute of Respiratory Medicine and Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Sun L; Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Zhong J; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Institute of Respiratory Medicine and Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.

J Cardiovasc Transl Res ; 17(1): 183-196, 2024 Feb.

Article em En | MEDLINE | ID: mdl-37603208

Assuntos

Cicloexilaminas; Hipertensão Pulmonar; Fenilenodiaminas; Hipertensão Arterial Pulmonar; Disfunção Ventricular Direita; Humanos; Ratos; Animais; Hipertrofia Ventricular Direita/etiologia; Hipertrofia Ventricular Direita/prevenção & controle; Hipertensão Arterial Pulmonar/tratamento farmacológico; Hipertensão Arterial Pulmonar/genética; Miócitos Cardíacos; Remodelação Ventricular; Modelos Animais de Doenças; Heme Oxigenase-1/genética; Heme Oxigenase-1/farmacologia; Heme Oxigenase-1/uso terapêutico

Palavras-chave

Differentially expressed genes; Ferroptosis; Heme oxygenase-1; Pulmonary arterial hypertension; Right ventricular remodeling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenilenodiaminas / Disfunção Ventricular Direita / Cicloexilaminas / Hipertensão Arterial Pulmonar / Hipertensão Pulmonar Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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