Cardiac miR-19a/19b was induced and hijacked by CVB3 to facilitate virus replication via targeting viral genomic RdRp-encoding region.

Wu, Yingchun; Yue, Yan; Xiong, Sidong

Wu, Yingchun; Yue, Yan; Xiong, Sidong.

Afiliação

Wu Y; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Yue Y; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China. Electronic address: yueyan@suda.edu.cn.
Xiong S; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China. Electronic address: sdxiong@suda.edu.cn.

Antiviral Res ; 217: 105702, 2023 09.

Article em En | MEDLINE | ID: mdl-37604350

Assuntos

Enterovirus Humano B; MicroRNAs; Miocardite; Miocárdio; Replicação Viral; Enterovirus Humano B/genética; Enterovirus Humano B/fisiologia; Miocardite/metabolismo; Miocardite/virologia; Miocárdio/metabolismo; Miocárdio/patologia; MicroRNAs/antagonistas & inibidores; MicroRNAs/metabolismo; Humanos; Replicação Viral/efeitos dos fármacos; Replicação Viral/genética; Genoma Viral; RNA Polimerase Dependente de RNA/genética; Antagomirs/farmacologia; Camundongos Endogâmicos BALB C; Células HEK293; Células HeLa; Camundongos; Animais

Palavras-chave

Coxsackievirus B3; RdRp; Viral genomic RNA stability; Viral myocarditis; miR-19a/19b

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Replicação Viral / Enterovirus Humano B / MicroRNAs / Miocardite / Miocárdio Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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