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Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits.
Brown, Andrew A; Fernandez-Tajes, Juan J; Hong, Mun-Gwan; Brorsson, Caroline A; Koivula, Robert W; Davtian, David; Dupuis, Théo; Sartori, Ambra; Michalettou, Theodora-Dafni; Forgie, Ian M; Adam, Jonathan; Allin, Kristine H; Caiazzo, Robert; Cederberg, Henna; De Masi, Federico; Elders, Petra J M; Giordano, Giuseppe N; Haid, Mark; Hansen, Torben; Hansen, Tue H; Hattersley, Andrew T; Heggie, Alison J; Howald, Cédric; Jones, Angus G; Kokkola, Tarja; Laakso, Markku; Mahajan, Anubha; Mari, Andrea; McDonald, Timothy J; McEvoy, Donna; Mourby, Miranda; Musholt, Petra B; Nilsson, Birgitte; Pattou, Francois; Penet, Deborah; Raverdy, Violeta; Ridderstråle, Martin; Romano, Luciana; Rutters, Femke; Sharma, Sapna; Teare, Harriet; 't Hart, Leen; Tsirigos, Konstantinos D; Vangipurapu, Jagadish; Vestergaard, Henrik; Brunak, Søren; Franks, Paul W; Frost, Gary; Grallert, Harald; Jablonka, Bernd.
Afiliação
  • Brown AA; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, United Kingdom.
  • Fernandez-Tajes JJ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom.
  • Hong MG; Science for Life Laboratory, School of Biotechnology, KTH - Royal Institute of Technology, Solna, SE-171 21, Sweden.
  • Brorsson CA; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.
  • Koivula RW; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK-2100, Denmark.
  • Davtian D; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, United Kingdom.
  • Dupuis T; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, United Kingdom.
  • Sartori A; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, United Kingdom.
  • Michalettou TD; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, 1211, Switzerland.
  • Forgie IM; Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, 1211, Switzerland.
  • Adam J; Swiss Institute of Bioinformatics, Geneva, 1211, Switzerland.
  • Allin KH; Biosciences Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, NE1 4EP, United Kingdom.
  • Caiazzo R; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, United Kingdom.
  • Cederberg H; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.
  • De Masi F; Research Unit of Molecular Epidemiology, Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, 85764, Germany.
  • Elders PJM; The Novo Nordisk Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, DK-2100, Denmark.
  • Giordano GN; University of Lille, Inserm, Lille Pasteur Institute, Lille, France.
  • Haid M; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
  • Hansen T; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.
  • Hansen TH; Department of General Practice, Amsterdam UMC- location Vumc, Amsterdam Public Health research institute, Amsterdam, The Netherlands.
  • Hattersley AT; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Malmö, Sweden.
  • Heggie AJ; Metabolomics and Proteomics Core, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, 85764, Germany.
  • Howald C; The Novo Nordisk Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, DK-2100, Denmark.
  • Jones AG; The Novo Nordisk Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, DK-2100, Denmark.
  • Kokkola T; Department of Clinical and Biomedical Sciences, University of Exeter College of Medicine & Health, Exeter, EX25DW, United Kingdom.
  • Laakso M; Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Mahajan A; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, 1211, Switzerland.
  • Mari A; Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, 1211, Switzerland.
  • McDonald TJ; Swiss Institute of Bioinformatics, Geneva, 1211, Switzerland.
  • McEvoy D; Department of Clinical and Biomedical Sciences, University of Exeter College of Medicine & Health, Exeter, EX25DW, United Kingdom.
  • Mourby M; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
  • Musholt PB; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
  • Nilsson B; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom.
  • Pattou F; Institute of Neuroscience, National Research Council, Padova, 35127, Italy.
  • Penet D; Blood Sciences, Royal Devon and Exeter NHS Foundation Trust, Exeter, EX2 5DW, United Kingdom.
  • Raverdy V; Diabetes Research Network, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.
  • Ridderstråle M; Nuffield Department of Population Health, Centre for Health, Law and Emerging Technologies (HeLEX), University of Oxford, Oxford, OX2 7DD, United Kingdom.
  • Romano L; Global Development, Sanofi-Aventis Deutschland GmbH, Hoechst Industrial Park, Frankfurt am Main, 65926, Germany.
  • Rutters F; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.
  • Sharma S; University of Lille, Inserm, Lille Pasteur Institute, Lille, France.
  • Teare H; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, 1211, Switzerland.
  • 't Hart L; Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, 1211, Switzerland.
  • Tsirigos KD; Swiss Institute of Bioinformatics, Geneva, 1211, Switzerland.
  • Vangipurapu J; University of Lille, Inserm, Lille Pasteur Institute, Lille, France.
  • Vestergaard H; Department of Clinical Science, Lund University, Malmö, Sweden.
  • Brunak S; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, 1211, Switzerland.
  • Franks PW; Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, 1211, Switzerland.
  • Frost G; Swiss Institute of Bioinformatics, Geneva, 1211, Switzerland.
  • Grallert H; Epidemiology and Data Science, VUMC, Amsterdam, The Netherlands.
  • Jablonka B; Research Unit of Molecular Epidemiology, Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, 85764, Germany.
Nat Commun ; 14(1): 5062, 2023 08 21.
Article em En | MEDLINE | ID: mdl-37604891
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Herança Multifatorial / Genômica Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Herança Multifatorial / Genômica Idioma: En Ano de publicação: 2023 Tipo de documento: Article