Antidepressant polyprenylated acylphloroglucinols from Hypericum ascyron.
J Asian Nat Prod Res
; 26(4): 474-481, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-37610120
ABSTRACT
Phytochemical investigation on the 90% EtOH extract of the air-dried aerial parts of Hypericum ascyron resulted in the isolation of three new polycyclic polyprenylated derivatives ascyronines A-C (1-3). Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy. All the polycyclic polyprenylated acylphloroglucinols were evaluated for their antidepressant activity by inhibiting the reuptake of tritiated serotonin ([3H]-5-HT) and noradrenalinet ([3H]-NE) in rat brain synaptosomes. Compounds 2 and 3 exhibited weak antidepressant activities in the [3H]-5-HT mode.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hypericum
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article