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Oxidative Stress in Type 2 Diabetes: Impacts from Pathogenesis to Lifestyle Modifications.
Caturano, Alfredo; D'Angelo, Margherita; Mormone, Andrea; Russo, Vincenzo; Mollica, Maria Pina; Salvatore, Teresa; Galiero, Raffaele; Rinaldi, Luca; Vetrano, Erica; Marfella, Raffaele; Monda, Marcellino; Giordano, Antonio; Sasso, Ferdinando Carlo.
Afiliação
  • Caturano A; Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I-80138 Naples, Italy.
  • D'Angelo M; Department of Experimental Medicine, University of Campania Luigi Vanvitelli, I-80138 Naples, Italy.
  • Mormone A; Department of Experimental Medicine, University of Campania Luigi Vanvitelli, I-80138 Naples, Italy.
  • Russo V; Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.
  • Mollica MP; Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I-80138 Naples, Italy.
  • Salvatore T; Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.
  • Galiero R; Division of Cardiology, Department of Medical Translational Sciences, University of Campania Luigi Vanvitelli, I-80138 Naples, Italy.
  • Rinaldi L; Department of Biology, University of Naples Federico II, I-80134 Naples, Italy.
  • Vetrano E; Department of Precision Medicine, University of Campania Luigi Vanvitelli, I-80138 Naples, Italy.
  • Marfella R; Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I-80138 Naples, Italy.
  • Monda M; Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I-80138 Naples, Italy.
  • Giordano A; Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I-80138 Naples, Italy.
  • Sasso FC; Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I-80138 Naples, Italy.
Curr Issues Mol Biol ; 45(8): 6651-6666, 2023 Aug 12.
Article em En | MEDLINE | ID: mdl-37623239
Oxidative stress is a critical factor in the pathogenesis and progression of diabetes and its associated complications. The imbalance between reactive oxygen species (ROS) production and the body's antioxidant defence mechanisms leads to cellular damage and dysfunction. In diabetes, chronic hyperglycaemia and mitochondrial dysfunction contribute to increased ROS production, further exacerbating oxidative stress. This oxidative burden adversely affects various aspects of diabetes, including impaired beta-cell function and insulin resistance, leading to disrupted glucose regulation. Additionally, oxidative stress-induced damage to blood vessels and impaired endothelial function contribute to the development of diabetic vascular complications such as retinopathy, nephropathy, and cardiovascular diseases. Moreover, organs and tissues throughout the body, including the kidneys, nerves, and eyes, are vulnerable to oxidative stress, resulting in diabetic nephropathy, neuropathy, and retinopathy. Strategies to mitigate oxidative stress in diabetes include antioxidant therapy, lifestyle modifications, and effective management of hyperglycaemia. However, further research is necessary to comprehensively understand the underlying mechanisms of oxidative stress in diabetes and to evaluate the efficacy of antioxidant interventions in preventing and treating diabetic complications. By addressing oxidative stress, it might be possible to alleviate the burden of diabetes and improve patient outcomes.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article