Lactate acidosis and simultaneous recruitment of TGF-ß leads to alter plasticity of hypoxic cancer cells in tumor microenvironment.

Rastogi, Saumya; Mishra, Shashank Shekher; Arora, Mandeep Kumar; Kaithwas, Gaurav; Banerjee, Sugato; Ravichandiran, Velayutham; Roy, Subhadeep; Singh, Lakhveer

Rastogi, Saumya; Mishra, Shashank Shekher; Arora, Mandeep Kumar; Kaithwas, Gaurav; Banerjee, Sugato; Ravichandiran, Velayutham; Roy, Subhadeep; Singh, Lakhveer.

Afiliação

Rastogi S; School of Pharmaceutical & Population Health Informatics, DIT University, Dehardun, Uttarakhand-248009, India.
Mishra SS; School of Pharmaceutical & Population Health Informatics, DIT University, Dehardun, Uttarakhand-248009, India.
Arora MK; School of Pharmaceutical & Population Health Informatics, DIT University, Dehardun, Uttarakhand-248009, India.
Kaithwas G; Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (A central university), Lucknow, Uttar Pradesh, India.
Banerjee S; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Kolkata, West Bengal 700054, India.
Ravichandiran V; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Kolkata, West Bengal 700054, India.
Roy S; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Kolkata, West Bengal 700054, India. Electronic address: subhadeep@niperkolkata.ac.in.
Singh L; School of Pharmaceutical & Population Health Informatics, DIT University, Dehardun, Uttarakhand-248009, India. Electronic address: Lakhveer@dituniversity.edu.in.

Pharmacol Ther ; 250: 108519, 2023 10.

Article em En | MEDLINE | ID: mdl-37625521

Assuntos

Acidose; Neoplasias; Humanos; Fator de Crescimento Transformador beta/metabolismo; Fator A de Crescimento do Endotélio Vascular/metabolismo; Ácido Láctico/metabolismo; Microambiente Tumoral; Hipóxia

Palavras-chave

Angiogenesis; Fatty acid synthesis; Hypoxia; Invasiveness; Transforming growth factor (TGF-ß)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acidose / Neoplasias Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acidose / Neoplasias Idioma: En Ano de publicação: 2023 Tipo de documento: Article