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Synthesis and biological evaluation of simplified ajudazol derivatives reveal potent 5-lipoxygenase inhibition and considerable apoptotic activity in neuroblastoma cells.
Wollnitzke, Philipp; Wagner, Raphael; Afsar, Sumaiya Yasmeen; Werner, Markus; Geschold, Robin; Müller, Christa E; Werz, Oliver; van Echten-Deckert, Gerhild; Menche, Dirk.
Afiliação
  • Wollnitzke P; Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.
  • Wagner R; Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.
  • Afsar SY; Life & Medical Science (LIMES) Institute for Membrane Biology and Lipid, Biochemistry at the Kekulé-Institute, University of Bonn, 53121 Bonn, Germany.
  • Werner M; Department of Pharmaceutical and Medicinal Chemistry Institute of Pharmacy, Friedrich Schiller University Jena, Philosophenweg 14, 07743 Jena, Germany.
  • Geschold R; Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, Universität Bonn, An der Immenburg 4, D-53121 Bonn, Germany.
  • Müller CE; Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, Universität Bonn, An der Immenburg 4, D-53121 Bonn, Germany.
  • Werz O; Department of Pharmaceutical and Medicinal Chemistry Institute of Pharmacy, Friedrich Schiller University Jena, Philosophenweg 14, 07743 Jena, Germany.
  • van Echten-Deckert G; Life & Medical Science (LIMES) Institute for Membrane Biology and Lipid, Biochemistry at the Kekulé-Institute, University of Bonn, 53121 Bonn, Germany. Electronic address: g.echten.deckert@uni-bonn.de.
  • Menche D; Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany. Electronic address: dirk.menche@uni-bonn.de.
Bioorg Med Chem Lett ; 94: 129464, 2023 10 01.
Article em En | MEDLINE | ID: mdl-37634760
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Inibidores de Lipoxigenase / Neuroblastoma Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Inibidores de Lipoxigenase / Neuroblastoma Idioma: En Ano de publicação: 2023 Tipo de documento: Article