A novel <sup>68</sup>Ga-labeled cyclic peptide molecular probe based on the computer-aided design for noninvasive imaging of PD-L1 expression in tumors.

Ge, Shushan; Zhang, Bin; Li, Jihui; Shi, Jinyu; Jia, Tongtong; Wang, Yan; Chen, Zhengguo; Sang, Shibiao; Deng, Shengming

A novel ⁶⁸Ga-labeled cyclic peptide molecular probe based on the computer-aided design for noninvasive imaging of PD-L1 expression in tumors.

Ge, Shushan; Zhang, Bin; Li, Jihui; Shi, Jinyu; Jia, Tongtong; Wang, Yan; Chen, Zhengguo; Sang, Shibiao; Deng, Shengming.

Afiliação

Ge S; Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China; Nuclear Medicine Laboratory of Mianyang Central Hospital, Mianyang 621099, China.
Zhang B; Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Li J; Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Shi J; Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Jia T; Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Wang Y; Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Chen Z; Nuclear Medicine Laboratory of Mianyang Central Hospital, Mianyang 621099, China. Electronic address: maiwang342@163.com.
Sang S; Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. Electronic address: sshibiao@163.com.
Deng S; Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China; Nuclear Medicine Laboratory of Mianyang Central Hospital, Mianyang 621099, China. Electronic address: dshming@163.com.

Bioorg Chem ; 140: 106785, 2023 11.

Article em En | MEDLINE | ID: mdl-37639759

Assuntos

Sondas Moleculares; Neoplasias; Humanos; Antígeno B7-H1; Radioisótopos de Gálio; Distribuição Tecidual; Desenho Assistido por Computador; Neoplasias/diagnóstico por imagem; Peptídeos Cíclicos

Palavras-chave

Immune checkpoint; Macrocyclic peptide radiotracer; Micro PET/CT; Molecular docking; Programmed death ligand 1; Tumor imaging

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sondas Moleculares / Neoplasias Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sondas Moleculares / Neoplasias Idioma: En Ano de publicação: 2023 Tipo de documento: Article