Inhibition of HDAC6 promotes microvascular endothelial cells to phagocytize myelin debris and reduces inflammatory response to accelerate the repair of spinal cord injury.

Wu, Chengjie; Pan, Yalan; Wang, Lining; Liu, Mengmin; Tu, Pengcheng; Chen, Sixian; Shi, Lei; Yan, Danqing; Ma, Yong; Guo, Yang

Wu, Chengjie; Pan, Yalan; Wang, Lining; Liu, Mengmin; Tu, Pengcheng; Chen, Sixian; Shi, Lei; Yan, Danqing; Ma, Yong; Guo, Yang.

Afiliação

Wu C; Department of Traumatology and Orthopedics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Pan Y; Laboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nanjing University of Chinese Medicine, Nanjing, China.
Wang L; Laboratory of Chinese Medicine Nursing Intervention for Chronic Diseases, Nanjing University of Chinese Medicine, Nanjing, China.
Liu M; School of Chinese Medicine, School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Tu P; School of Chinese Medicine, School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Chen S; Department of Traumatology and Orthopedics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Shi L; Laboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nanjing University of Chinese Medicine, Nanjing, China.
Yan D; School of Chinese Medicine, School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Ma Y; School of Chinese Medicine, School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Guo Y; Department of Traumatology and Orthopedics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

CNS Neurosci Ther ; 30(3): e14439, 2024 03.

Article em En | MEDLINE | ID: mdl-37641882

Assuntos

Bainha de Mielina; Traumatismos da Medula Espinal; Humanos; Células Endoteliais/metabolismo; Desacetilase 6 de Histona/antagonistas & inibidores; Desacetilase 6 de Histona/metabolismo; Imunoglobulina G/farmacologia; Imunoglobulina M/metabolismo; Macrófagos; Bainha de Mielina/metabolismo; Medula Espinal/metabolismo; Traumatismos da Medula Espinal/tratamento farmacológico; Traumatismos da Medula Espinal/metabolismo

Palavras-chave

HDAC6; autophagy-lysosome; immune regulation; inflammatory response; microvascular endothelial cells; myelin debris; spinal cord injury

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Bainha de Mielina Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Bainha de Mielina Idioma: En Ano de publicação: 2024 Tipo de documento: Article