The global anaerobic metabolism regulator fnr is necessary for the degradation of food dyes and drugs by Escherichia coli.
mBio
; 14(5): e0157323, 2023 Oct 31.
Article
em En
| MEDLINE
| ID: mdl-37642463
ABSTRACT
IMPORTANCE This work has broad relevance due to the ubiquity of dyes containing azo bonds in food and drugs. We report that azo dyes can be degraded by human gut bacteria through both enzymatic and nonenzymatic mechanisms, even from a single gut bacterial species. Furthermore, we revealed that environmental factors, oxygen, and L-Cysteine control the ability of E. coli to degrade azo dyes due to their impacts on bacterial transcription and metabolism. These results open up new opportunities to manipulate the azoreductase activity of the gut microbiome through the manipulation of host diet, suggest that azoreductase potential may be altered in patients suffering from gastrointestinal disease, and highlight the importance of studying bacterial enzymes for drug metabolism in their natural cellular and ecological context.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Escherichia coli
/
Proteínas Ferro-Enxofre
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article