Risk management actions following genetic testing in the Cancer Health Assessments Reaching Many (CHARM) Study: A prospective cohort study.
Cancer Med
; 12(18): 19112-19125, 2023 Sep.
Article
em En
| MEDLINE
| ID: mdl-37644850
ABSTRACT
BACKGROUND:
Genetic testing can identify cancer risk early, enabling prevention and early detection. We describe use of risk management interventions following genetic testing in the Cancer Health Assessment Reaching Many (CHARM) study. CHARM assessed risk and provided genetic testing to low income, low literacy, and other underserved populations that historically face barriers to accessing cancer genetic services.METHODS:
CHARM was implemented in Kaiser Permanente Northwest (KPNW) and Denver Health (DH) between 2018 and 2020. We identified post-testing screening (mammography, breast MRI, colonoscopy) and surgical (mastectomy, oophorectomy) procedures using electronic health records. We examined utilization in participants who did and did not receive actionable risk management recommendations from study genetic counselors following national guidelines.RESULTS:
CHARM participants were followed for an average of 15.4 months (range 0.4-27.8 months) after results disclosure. Less than 2% (11/680) received actionable risk management recommendations (i.e., could be completed in the initial years following testing) based on their test result. Among those who received actionable recommendations, risk management utilization was moderate (54.5%, 6/11 completed any procedure) and varied by procedure (mammogram 0/3; MRI 2/4; colonoscopy 4/5; mastectomy 1/5; oophorectomy 0/3). Cancer screening and surgery procedures were rare in participants without actionable recommendations.CONCLUSION:
Though the number of participants who received actionable risk management recommendations was small, our results suggest that implementing CHARM's risk assessment and testing model increased access to evidence-based genetic services and provided opportunities for patients to engage in recommended preventive care, without encouraging risk management overuse.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article