Persistent hypoxia promotes myofibroblast differentiation via GPR-81 and differential regulation of LDH isoenzymes in normal and idiopathic pulmonary fibrosis fibroblasts.

Nho, Richard S; Rice, Cami; Prasad, Jayendra; Bone, Hannah; Farkas, Laszlo; Rojas, Mauricio; Horowitz, Jeffrey C

Nho, Richard S; Rice, Cami; Prasad, Jayendra; Bone, Hannah; Farkas, Laszlo; Rojas, Mauricio; Horowitz, Jeffrey C.

Afiliação

Nho RS; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Rice C; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Prasad J; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Bone H; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Farkas L; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Rojas M; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Horowitz JC; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.

Physiol Rep ; 11(17): e15759, 2023 09.

Article em En | MEDLINE | ID: mdl-37653539

Assuntos

Fibrose Pulmonar Idiopática; Isoenzimas; Humanos; Miofibroblastos; L-Lactato Desidrogenase; Fibroblastos; Ácido Láctico; Hipóxia; Oxigênio

Palavras-chave

G protein-coupled receptor-81 (GPR-81); hypoxia; idiopathic pulmonary fibrosis (IPF); lactate dehydrogenase; α-smooth muscle actin (α-SMA)

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar Idiopática / Isoenzimas Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar Idiopática / Isoenzimas Idioma: En Ano de publicação: 2023 Tipo de documento: Article