Interplay of Ebola Virus With Immune Cells Leading to Their Death by Diverse Mechanisms.
J Infect Dis
; 228(Suppl 7): S582-S586, 2023 11 13.
Article
em En
| MEDLINE
| ID: mdl-37654044
ABSTRACT
Inflammation and cytopenia are commonly observed during Ebola virus (EBOV) infection; however, mechanisms responsible for EBOV-induced cell death remain obscure. While apoptosis and necrosis are already identified as mechanisms of cell death induced by the virus, our study demonstrates that THP-1 monocytes and SupT1 T cells exposed to EBOV undergo pyroptosis and necroptosis, respectively, through a direct contact with EBOV, and also mediate pyroptosis or necroptosis of uninfected bystander cells via indirect effects associated with secreted soluble factors. These results emphasize novel aspects of interactions between EBOV and immune cell populations and provide a better understanding of the immunopathogenesis of EBOV disease.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doença pelo Vírus Ebola
/
Ebolavirus
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article