Trajectories of cognitive and perceived functional decline in people with dementia: Findings from the IDEAL programme.
Alzheimers Dement
; 20(1): 410-420, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-37658739
ABSTRACT
INTRODUCTION:
Impaired cognition and instrumental activities of daily living (iADL) are key diagnostic features of dementia; however, few studies have compared trajectories of cognition and iADL.METHODS:
Participants from the IDEAL study comprised 1537, 1183, and 851 people with dementia, and 1277, 977, and 749 caregivers at baseline, 12 and 24 months, respectively. Addenbrooke's Cognitive Examination-III and Functional Activities Questionnaire were used to measure cognition and iADL, respectively. Scores were converted to deciles.RESULTS:
Self-rated iADL declined on average by -0.08 (-0.25, 0.08) decile points per timepoint more than cognition. Informant-rated iADL declined on average by -0.31 (-0.43, -0.18) decile points per timepoint more than cognition.DISCUSSION:
Cognition and self-rated iADL declined at a similar rate. Informant-rated iADL declined at a significantly greater rate than cognition. Therefore, either cognition and perceived iADL decline at different rates or informants overestimate increasing iADL difficulties compared to both cognition and self-ratings. HIGHLIGHTS Self-ratings of the degree of functional difficulties were consistent with cognition Decline in self-rated everyday activities was consistent with cognitive decline Informant-ratings of everyday activities declined more than cognition.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Demência
/
Disfunção Cognitiva
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article