Monoterpenoid indole alkaloid dimers from the Melodinus axillaris induce G2/M phase arrest and apoptosis via p38 MAPK activation in HCT116 cells.

Du, Kaicheng; Li, Xingyao; Zheng, Changwei; Lai, Lantao; Shen, Mingyi; Wang, Yumeng; Meng, Dali

Du, Kaicheng; Li, Xingyao; Zheng, Changwei; Lai, Lantao; Shen, Mingyi; Wang, Yumeng; Meng, Dali.

Afiliação

Du K; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Li X; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Zheng C; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Lai L; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Shen M; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Wang Y; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Meng D; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: mengdl@163.com.

Bioorg Chem ; 140: 106841, 2023 11.

Article em En | MEDLINE | ID: mdl-37683541

Assuntos

Apocynaceae; Alcaloides de Triptamina e Secologanina; Humanos; Células HCT116; Simulação de Acoplamento Molecular; Apoptose; Pontos de Checagem do Ciclo Celular; Alcaloides Indólicos; Mitose; Monoterpenos/farmacologia; Polímeros

Palavras-chave

Alkaloid dimers; Apocynaceae; Apoptosis; Cell cycle; Cytotoxicity; Melodinus axillaris

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apocynaceae / Alcaloides de Triptamina e Secologanina Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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