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Binge Eating (BE) and Obesity: Brain Activity and Psychological Measures before and after Roux-En-Y Gastric Bypass (RYGB).
Baboumian, Shaunte; Puma, Lauren; Swencionis, Charles; Astbury, Nerys M; Ho, Jennifer; Pantazatos, Spiro P; Geliebter, Allan.
Afiliação
  • Baboumian S; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Mount Sinai Morningside, 1111 Amsterdam Ave, New York, NY 10025, USA.
  • Puma L; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Mount Sinai Morningside, 1111 Amsterdam Ave, New York, NY 10025, USA.
  • Swencionis C; Ferkauf Graduate School of Psychology, Yeshiva University, 500 West 185th Street, New York, NY 10033, USA.
  • Astbury NM; Nuffield Department of Primary Care Health Sciences, Medical Sciences Division, University of Oxford, Oxford OX2 6GG, UK.
  • Ho J; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Mount Sinai Morningside, 1111 Amsterdam Ave, New York, NY 10025, USA.
  • Pantazatos SP; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, Department of Psychiatry, Columbia University Irving Medical Center, 1051 Riverside Dr, New York, NY 10032, USA.
  • Geliebter A; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Mount Sinai Morningside, 1111 Amsterdam Ave, New York, NY 10025, USA.
Nutrients ; 15(17)2023 Aug 31.
Article em En | MEDLINE | ID: mdl-37686840
Brain activity in response to food cues following Roux-En-Y Gastric Bypass (RYGB) in binge eating (BE) or non-binge eating (NB) individuals is understudied. Here, 15 RYGB (8 BE; 7 NB) and 13 no treatment (NT) (7 BE; 6 NB) women with obesity underwent fMRI imaging while viewing high and low energy density food (HEF and LEF, respectively) and non-food (NF) visual cues. A region of interest (ROI) analysis compared BE participants to NB participants in those undergoing RYGB surgery pre-surgery and 4 months post. Results were corrected for multiple comparisons using liberal (p < 0.006 uncorrected) and stringent (p < 0.05 FDR corrected) thresholds. Four months following RYGB (vs. no treatment (NT) control), both BE and NB participants showed greater reductions in blood oxygen level-dependent (BOLD) signals (a proxy of local brain activity) in the dorsomedial prefrontal cortex in response to HEF (vs. LEF) cues (p < 0.006). BE (vs. NB) participants showed greater increases in the precuneus (p < 0.006) and thalamic regions (p < 0.05 corrected) to food (vs. NF). For RYGB (vs. NT) participants, BE participants, but not NB participants, showed lower BOLD signal in the middle occipital gyrus (p < 0.006), whilst NB participants, but not BE participants, showed lower signal in inferior frontal gyrus (p < 0.006) in response to HEF (vs. LEF). Results suggest distinct neural mechanisms of RGYB in BE and may help lead to improved clinical treatments.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Derivação Gástrica / Bulimia / Transtorno da Compulsão Alimentar Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Derivação Gástrica / Bulimia / Transtorno da Compulsão Alimentar Idioma: En Ano de publicação: 2023 Tipo de documento: Article