Reducing diagnostic delays in Acute Hepatic Porphyria using electronic health records data and machine learning: a multicenter development and validation study.

Bhasuran, Balu; Schmolly, Katharina; Kapoor, Yuvraaj; Jayakumar, Nanditha Lakshmi; Doan, Raymond; Amin, Jigar; Meninger, Stephen; Cheng, Nathan; Deering, Robert; Anderson, Karl; Beaven, Simon W; Wang, Bruce; Rudrapatna, Vivek A

Bhasuran, Balu; Schmolly, Katharina; Kapoor, Yuvraaj; Jayakumar, Nanditha Lakshmi; Doan, Raymond; Amin, Jigar; Meninger, Stephen; Cheng, Nathan; Deering, Robert; Anderson, Karl; Beaven, Simon W; Wang, Bruce; Rudrapatna, Vivek A.

Afiliação

Bhasuran B; Bakar Computational Health Sciences Institute, San Francisco, CA, 94143.
Schmolly K; David Geffen School of Medicine & Pfleger Liver Institute, University of California Los Angeles, Los Angeles, CA 90095.
Kapoor Y; Department of Medicine, University of California San Francisco, San Francisco, CA, 94143.
Jayakumar NL; Department of Medicine, University of California San Francisco, San Francisco, CA, 94143.
Doan R; Alnylam Pharmaceuticals, Cambridge, Massachusetts, MA 02142.
Amin J; Alnylam Pharmaceuticals, Cambridge, Massachusetts, MA 02142.
Meninger S; Alnylam Pharmaceuticals, Cambridge, Massachusetts, MA 02142.
Cheng N; Alnylam Pharmaceuticals, Cambridge, Massachusetts, MA 02142.
Deering R; Alnylam Pharmaceuticals, Cambridge, Massachusetts, MA 02142.
Anderson K; Division of Gastroenterology and Hepatology, University of Texas Medical Branch, School of Medicine, Galveston, TX, 77555.
Beaven SW; David Geffen School of Medicine & Pfleger Liver Institute, University of California Los Angeles, Los Angeles, CA 90095.
Wang B; Department of Medicine, University of California San Francisco, San Francisco, CA, 94143.
Rudrapatna VA; Bakar Computational Health Sciences Institute, San Francisco, CA, 94143.

medRxiv ; 2023 Aug 31.

Article em En | MEDLINE | ID: mdl-37693437

Palavras-chave

Rare disease prediction; acute hepatic porphyria; acute intermittent porphyria; artificial intelligence; automated diagnosis; causal models; data science; directed acyclic graphs; knowledge graphs; machine learning; natural language processing; prospective study

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article