KRASG12D inhibition in pancreatic cancer: Fas expression facilitates immune clearance.
Dev Cell
; 58(17): 1515-1516, 2023 09 11.
Article
em En
| MEDLINE
| ID: mdl-37699334
ABSTRACT
In an article in this issue of Developmental Cell and in a second paper in Cancer Cell, Mahadevan et al. demonstrate that KrasG12D suppression remodels the immunosuppressive microenvironment of KrasG12D pancreatic cancers, recruits activated CD8+ cytotoxic T cells, and epigenetically upregulates Fas expression in cancer cells, leading to tumor clearance via Fas/FasL-mediated apoptosis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Proteínas Proto-Oncogênicas p21(ras)
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article