Role of Translesion DNA Synthesis in the Metabolism of Replication-associated Nascent Strand Gaps.
J Mol Biol
; 436(1): 168275, 2024 01 01.
Article
em En
| MEDLINE
| ID: mdl-37714300
ABSTRACT
Translesion DNA synthesis (TLS) is a DNA damage tolerance pathway utilized by cells to overcome lesions encountered throughout DNA replication. During replication stress, cancer cells show increased dependency on TLS proteins for cellular survival and chemoresistance. TLS proteins have been described to be involved in various DNA repair pathways. One of the major emerging roles of TLS is single-stranded DNA (ssDNA) gap-filling, primarily after the repriming activity of PrimPol upon encountering a lesion. Conversely, suppression of ssDNA gap accumulation by TLS is considered to represent a mechanism for cancer cells to evade the toxicity of chemotherapeutic agents, specifically in BRCA-deficient cells. Thus, TLS inhibition is emerging as a potential treatment regimen for DNA repair-deficient tumors.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
DNA de Cadeia Simples
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DNA Primase
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DNA Polimerase Dirigida por DNA
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Reparo do DNA
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Enzimas Multifuncionais
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Síntese de DNA Translesão
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article