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Schiff Base Reaction in a Living Cell: In Situ Synthesis of a Hollow Covalent Organic Polymer To Regulate Biological Functions.
Xu, Han-Bin; Chen, Hua-Ying; Lv, Jian; Chen, Bin-Bin; Zhou, Ze-Rui; Chang, Shuai; Gao, Ya-Ting; Huang, Wen-Fei; Ye, Ming-Jie; Cheng, Zi-Jian; Hafez, Mahmoud Elsayed; Qian, Ruo-Can; Li, Da-Wei.
Afiliação
  • Xu HB; Key Laboratory for Advanced Materials, Shanghai Key Laboratory of Functional Materials Chemistry, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology & Dynamic Chemistry, School of Chemistry & Molecular Engineering, East China University of Scienc
  • Chen HY; Key Laboratory for Advanced Materials, Shanghai Key Laboratory of Functional Materials Chemistry, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology & Dynamic Chemistry, School of Chemistry & Molecular Engineering, East China University of Scienc
  • Lv J; Key Laboratory for Advanced Materials, Shanghai Key Laboratory of Functional Materials Chemistry, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology & Dynamic Chemistry, School of Chemistry & Molecular Engineering, East China University of Scienc
  • Chen BB; Key Laboratory for Advanced Materials, Shanghai Key Laboratory of Functional Materials Chemistry, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology & Dynamic Chemistry, School of Chemistry & Molecular Engineering, East China University of Scienc
  • Zhou ZR; School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen City, Guangdong, 518172, P. R. China.
  • Chang S; Key Laboratory for Advanced Materials, Shanghai Key Laboratory of Functional Materials Chemistry, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology & Dynamic Chemistry, School of Chemistry & Molecular Engineering, East China University of Scienc
  • Gao YT; Key Laboratory for Advanced Materials, Shanghai Key Laboratory of Functional Materials Chemistry, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology & Dynamic Chemistry, School of Chemistry & Molecular Engineering, East China University of Scienc
  • Huang WF; Key Laboratory for Advanced Materials, Shanghai Key Laboratory of Functional Materials Chemistry, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology & Dynamic Chemistry, School of Chemistry & Molecular Engineering, East China University of Scienc
  • Ye MJ; Key Laboratory for Advanced Materials, Shanghai Key Laboratory of Functional Materials Chemistry, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology & Dynamic Chemistry, School of Chemistry & Molecular Engineering, East China University of Scienc
  • Cheng ZJ; Key Laboratory for Advanced Materials, Shanghai Key Laboratory of Functional Materials Chemistry, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology & Dynamic Chemistry, School of Chemistry & Molecular Engineering, East China University of Scienc
  • Hafez ME; Key Laboratory for Advanced Materials, Shanghai Key Laboratory of Functional Materials Chemistry, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology & Dynamic Chemistry, School of Chemistry & Molecular Engineering, East China University of Scienc
  • Qian RC; Key Laboratory for Advanced Materials, Shanghai Key Laboratory of Functional Materials Chemistry, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology & Dynamic Chemistry, School of Chemistry & Molecular Engineering, East China University of Scienc
  • Li DW; Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef, 62511, Egypt.
Angew Chem Int Ed Engl ; 62(44): e202311002, 2023 10 26.
Article em En | MEDLINE | ID: mdl-37714815
ABSTRACT
Artificially performing chemical reactions in living biosystems to attain various physiological aims remains an intriguing but very challenging task. In this study, the Schiff base reaction was conducted in cells using Sc(OTf)3 as a catalyst, enabling the in situ synthesis of a hollow covalent organic polymer (HCOP) without external stimuli. The reversible Schiff base reaction mediated intracellular Oswald ripening endows the HCOP with a spherical, hollow porous structure and a large specific surface area. The intracellularly generated HCOP reduced cellular motility by restraining actin polymerization, which consequently induced mitochondrial deactivation, apoptosis, and necroptosis. The presented intracellular synthesis system inspired by the Schiff base reaction has strong potential to regulate cell fate and biological functions, opening up a new strategic possibility for intervening in cellular behavior.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polímeros / Bases de Schiff Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polímeros / Bases de Schiff Idioma: En Ano de publicação: 2023 Tipo de documento: Article