Deep learning-based recurrence detector on magnetic resonance scans in nasopharyngeal carcinoma: A multicenter study.

ABSTRACT

OBJECTIVES: Accuracy in the detection of recurrent nasopharyngeal carcinoma (NPC) on follow-up magnetic resonance (MR) scans needs to be improved. MATERIAL AND METHODS: A total of 5 035 follow-up MR scans from 5 035 survivors with treated NPC between April 2007 and July 2020 were retrospectively collected from three cancer centers for developing and evaluating the deep learning (DL) model MODERN (MR-based Deep learning model for dEtecting Recurrent Nasopharyngeal carcinoma). In a reader study with 220 scans, the accuracy of two radiologists in detecting recurrence on scans with vs without MODERN was evaluated. The performance was measured using the area under the receiver operating characteristic curve (ROC-AUC) and accuracy with a 95% confidence interval (CI). RESULTS: MODERN exhibited sound performance in the validation cohort (internal ROC-AUC, 0.88, 95% CI, 0.86-0.90; external 1 ROC-AUC, 0.88, 95% CI, 0.86-0.90; external 2 ROC-AUC, 0.85, 95% CI, 0.82-0.88). In a reader study, MODERN alone achieved reliable accuracy compared to that of radiologists (MODERN 84.1%, 95% CI, 79.3%-88.9%; competent 80.9%, 95% CI, 75.7%-86.1%, P < 0.001; expert 85.9%, 95% CI, 81.3%-90.5%, P < 0.001). The accuracy of radiologists was boosted by the MODERN score (competent with MODERN score 84.6%, 95% CI, 79.8%-89.3%, P < 0.001; expert with MODERN score 87.7%, 95% CI, 83.4%-92.1%, P < 0.001). CONCLUSION: We developed a DL model for recurrence detection with reliable performance. Computer-human collaboration has the potential to refine the workflow in interpreting surveillant MR scans among patients with treated NPC.