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Probiotics in septic acute kidney injury, a double blind, randomized control trial.
Chávez-Íñiguez, Jonathan S; Ibarra-Estrada, Miguel; Gallardo-González, Alejandro Martínez; Cisneros-Hernández, Ari; Claure-Del Granado, Rolando; Chávez-Alonso, Gael; Hernández-Barajas, Eduardo M; Romero-Muñoz, Alexia C; Ramos-Avellaneda, Fidel; Prieto-Magallanes, Manuel L; Plascencia-Cruz, Marcela; Tanaka-Gutiérrez, Jarumi A; Pérez-Hernández, Cristina; Navarro-Blackaller, Guillermo; Medina-González, Ramón; Alcantar-Vallin, Luz; Renoirte-López, Karina; García-García, Guillermo.
Afiliação
  • Chávez-Íñiguez JS; Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico.
  • Ibarra-Estrada M; Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
  • Gallardo-González AM; Intensive Care Unit, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico.
  • Cisneros-Hernández A; Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico.
  • Claure-Del Granado R; Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
  • Chávez-Alonso G; Division of Nutrition, NIN Institute, Guadalajara, Jalisco, México.
  • Hernández-Barajas EM; Division of Nephrology, Hospital Obrero #2 - C.N.S, Universidad Mayor de San Simon School of Medicine, Cochabamba, Bolivia.
  • Romero-Muñoz AC; Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
  • Ramos-Avellaneda F; Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
  • Prieto-Magallanes ML; Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico.
  • Plascencia-Cruz M; Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
  • Tanaka-Gutiérrez JA; Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico.
  • Pérez-Hernández C; Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
  • Navarro-Blackaller G; Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico.
  • Medina-González R; Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
  • Alcantar-Vallin L; Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico.
  • Renoirte-López K; Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
  • García-García G; Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
Ren Fail ; 45(2): 2260003, 2023.
Article em En | MEDLINE | ID: mdl-37724527
ABSTRACT

INTRODUCTION:

During acute kidney injury (AKI) due to sepsis, the intestinal microbiota changes to dysbiosis, which affects the kidney function recovery (KFR) and amplifies the injury. Therefore, the administration of probiotics could improve dysbiosis and thereby increase the probability of KFR.

METHODS:

In this double-blind clinical trial, patients with AKI associated with sepsis were randomized (11) to receive probiotics or placebo for 7 consecutive days, with the objectives of evaluate the effect on KFR, mortality, kidney replacement therapy (KRT), urea, urine volume, serum electrolytes and adverse events at day 7.

RESULTS:

From February 2019 to March 2022, a total of 92 patients were randomized, 48 to the Probiotic and 44 to Placebo group. When comparing with placebo, those in the Probiotics did not observe a higher KFR (HR 0.93, 0.52-1.68, p = 0.81), nor was there a benefit in mortality at 6 months (95% CI 0.32-1.04, p = 0.06). With probiotics, urea values decreased significantly, an event not observed with placebo (from 154 to 80 mg/dl, p = 0.04 and from 130 to 109 mg/dl, p = 0.09, respectively). Urinary volume, need for KRT, electrolyte abnormalities, and adverse events were similar between groups. (ClinicalTrial.gov NCT03877081) (registered 03/15/2019).

CONCLUSION:

In AKI related to sepsis, probiotics for 7 consecutive days did not increase the probability of KFR, nor did other variables related to clinical improvement, although they were safe.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sepse / Probióticos / Injúria Renal Aguda Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sepse / Probióticos / Injúria Renal Aguda Idioma: En Ano de publicação: 2023 Tipo de documento: Article