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Multifaceted neural and vascular pathologies after pediatric mild traumatic brain injury.
Mayer, Andrew R; Dodd, Andrew B; Robertson-Benta, Cidney R; Zotev, Vadim; Ryman, Sephira G; Meier, Timothy B; Campbell, Richard A; Phillips, John P; van der Horn, Harm J; Hogeveen, Jeremy; Tarawneh, Rawan; Sapien, Robert E.
Afiliação
  • Mayer AR; The Mind Research Network/LBERI, Albuquerque, NM, USA.
  • Dodd AB; Department of Psychology, University of New Mexico, Albuquerque, NM, USA.
  • Robertson-Benta CR; Department of Neurology, University of New Mexico, Albuquerque, NM, USA.
  • Zotev V; Department of Psychiatry & Behavioral Sciences, University of New Mexico, Albuquerque, NM, USA.
  • Ryman SG; The Mind Research Network/LBERI, Albuquerque, NM, USA.
  • Meier TB; The Mind Research Network/LBERI, Albuquerque, NM, USA.
  • Campbell RA; The Mind Research Network/LBERI, Albuquerque, NM, USA.
  • Phillips JP; The Mind Research Network/LBERI, Albuquerque, NM, USA.
  • van der Horn HJ; Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Hogeveen J; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Tarawneh R; Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Sapien RE; Department of Psychiatry & Behavioral Sciences, University of New Mexico, Albuquerque, NM, USA.
J Cereb Blood Flow Metab ; 44(1): 118-130, 2024 01.
Article em En | MEDLINE | ID: mdl-37724718
ABSTRACT
Dynamic changes in neurodevelopment and cognitive functioning occur during adolescence, including a switch from reactive to more proactive forms of cognitive control, including response inhibition. Pediatric mild traumatic brain injury (pmTBI) affects these cognitions immediately post-injury, but the role of vascular versus neural injury in cognitive dysfunction remains debated. This study consecutively recruited 214 sub-acute pmTBI (8-18 years) and age/sex-matched healthy controls (HC; N = 186), with high retention rates (>80%) at four months post-injury. Multimodal imaging (functional MRI during response inhibition, cerebral blood flow and cerebrovascular reactivity) assessed for pathologies within the neurovascular unit. Patients exhibited increased errors of commission and hypoactivation of motor circuitry during processing of probes. Evidence of increased/delayed cerebrovascular reactivity within motor circuitry during hypercapnia was present along with normal perfusion. Neither age-at-injury nor post-concussive symptom load were strongly associated with imaging abnormalities. Collectively, mild cognitive impairments and clinical symptoms may continue up to four months post-injury. Prolonged dysfunction within the neurovascular unit was observed during proactive response inhibition, with preliminary evidence that neural and pure vascular trauma are statistically independent. These findings suggest pmTBI is characterized by multifaceted pathologies during the sub-acute injury stage that persist several months post-injury.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Concussão Encefálica / Síndrome Pós-Concussão / Disfunção Cognitiva / Lesões Encefálicas Traumáticas Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Concussão Encefálica / Síndrome Pós-Concussão / Disfunção Cognitiva / Lesões Encefálicas Traumáticas Idioma: En Ano de publicação: 2024 Tipo de documento: Article