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Compartmental tongue surgery for intermediate-advanced squamous cell carcinoma: A multicentric study.
Calabrese, Luca; Tagliabue, Marta; Grammatica, Alberto; De Berardinis, Rita; Corso, Federica; Gazzini, Luca; Abousiam, Monir; Fazio, Enrico; Mattavelli, Davide; Fontanella, Walter; Giannini, Lorenzo; Bresciani, Lorenzo; Bruschini, Roberto; Gandini, Sara; Piazza, Cesare; Ansarin, Mohssen.
Afiliação
  • Calabrese L; Department of Otolaryngology-Head and Neck Surgery, Hospital of Bolzano (SABES-ASDAA), Teaching Hospital of the Paracelsus Medical Private University (PMU), Bolzano, Italy.
  • Tagliabue M; Department of Otorhinolaryngology and Head and Neck Surgery, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Grammatica A; Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
  • De Berardinis R; Unit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili of Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, School of Medicine, Brescia, Italy.
  • Corso F; Department of Otorhinolaryngology and Head and Neck Surgery, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Gazzini L; Department of Mathematics (DMAT), Politecnico di Milano, Milan, Italy.
  • Abousiam M; Centre for Health Data Science (CHDS), Human Techonopole, Milan, Italy.
  • Fazio E; Department of Otolaryngology-Head and Neck Surgery, Hospital of Bolzano (SABES-ASDAA), Teaching Hospital of the Paracelsus Medical Private University (PMU), Bolzano, Italy.
  • Mattavelli D; Department of Otolaryngology-Head and Neck Surgery, Hospital of Bolzano (SABES-ASDAA), Teaching Hospital of the Paracelsus Medical Private University (PMU), Bolzano, Italy.
  • Fontanella W; Department of Otolaryngology-Head and Neck Surgery, Hospital of Bolzano (SABES-ASDAA), Teaching Hospital of the Paracelsus Medical Private University (PMU), Bolzano, Italy.
  • Giannini L; Unit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili of Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, School of Medicine, Brescia, Italy.
  • Bresciani L; Department of Otorhinolaryngology, Maxillofacial, and Thyroid Surgery, Fondazione IRCCS National Cancer Institute of Milan, Milan, Italy.
  • Bruschini R; Department of Otorhinolaryngology, Maxillofacial, and Thyroid Surgery, Fondazione IRCCS National Cancer Institute of Milan, Milan, Italy.
  • Gandini S; Department of Otorhinolaryngology, Maxillofacial, and Thyroid Surgery, Fondazione IRCCS National Cancer Institute of Milan, Milan, Italy.
  • Piazza C; Department of Otorhinolaryngology and Head and Neck Surgery, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Ansarin M; Department of Experimental Oncology, IEO European Institute of Experimental Oncology IRCCS, Milan, Italy.
Head Neck ; 45(11): 2862-2873, 2023 11.
Article em En | MEDLINE | ID: mdl-37727894
ABSTRACT

BACKGROUND:

A multicentric study was conducted on technical reproducibility of compartmental tongue surgery (CTS) in advanced tongue cancers (OTSCC) and comparison to standard wide margin surgery (SWMS).

METHODS:

We studied 551 patients with OTSCC treated by CTS and 50 by SWMS. Oncological outcomes were analyzed. A propensity score was performed to compare survival endpoints for the two cohorts.

RESULTS:

In the CTS group, survival and prognosis were significantly associated with positive lymph-nodes, extranodal extension, depth of invasion and involvement of the soft tissue connecting the tongue primary tumor to neck lymph nodes (T-N tract), independently from the center performing the surgery. SWMS versus CTS showed a HR Cause-Specific Survival (CSS) of 3.24 (95% CI 1.71-6.11; p < 0.001); HR Loco-Regional Recurrence Free Survival (LRRFS) of 2.54 (95% CI 1.47-4.40; p < 0.001); HR Overall Survival (OS) of 0.11 (95% CI 0.01-0.77; p = 0.03).

CONCLUSION:

Performing the CTS could provide better CSS and LRRFS than SWMS regardless of the center performing the surgery, in advanced OTSSC.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Língua / Carcinoma de Células Escamosas Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Língua / Carcinoma de Células Escamosas Idioma: En Ano de publicação: 2023 Tipo de documento: Article