To target or not to target? The role of DNA and histone methylation in bacterial infections.
Epigenetics
; 18(1): 2242689, 2023 12.
Article
em En
| MEDLINE
| ID: mdl-37731322
ABSTRACT
Epigenetics describes chemical modifications of the genome that do not alter DNA sequence but participate in the regulation of gene expression and cellular processes such as proliferation, division, and differentiation of eukaryotic cell. Disruption of the epigenome pattern in a human cell is associated with different diseases, including infectious diseases. During infection pathogens induce epigenetic modifications in the host cell. This can occur by controlling expression of genes involved in immune response. That enables bacterial survival and replication within the host and evasion of the immune response. Methylation is an example of epigenetic modification that occurs on DNA and histones. Reasoning that DNA and histone methylation of human host cells plays a crucial role during pathogenesis, these modifications are promising targets for the development of alternative treatment strategies in infectious diseases. Here, we discuss the role of DNA and histone methyltransferases in human host cell upon bacterial infections. We further hypothesize that compounds targeting methyltransferases are tools to study epigenetics in the context of host-pathogen interactions and can open new avenues for the treatment of bacterial infections.
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Base de dados:
MEDLINE
Assunto principal:
Infecções Bacterianas
/
Doenças Transmissíveis
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article