Prevalence of atrial septal defects and patent foramen ovale in a cohort of sudden cardiac death patients undergoing autopsy.
J Cardiol
; 83(6): 390-393, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-37734655
ABSTRACT
BACKGROUND:
Patent foramen ovale (PFO) and atrial septal defects (ASD) have been described in up to 30â¯% of subjects in autopsy series but contemporary data are scarce. It is important to confirm the prevalence of ASD/PFO in the general population given the potential associated stroke risk and the increasing availability of intervention via PFO closure.METHODS:
A state-wide prospective out-of-hospital cardiac arrest registry (OHCA) identified all patients aged 1 to 50â¯years who experienced OHCA in Victoria, Australia from April 2019 to April 2022 and subsequently underwent autopsy with a cardiac cause of death identified. Autopsy was performed including visual description of any ASD and identification of probe patency of foramen ovale.RESULTS:
A total of 517 patients underwent autopsy in the setting of sudden cardiac death; 36 patients (6.9â¯%) had a probe-patent foramen ovale, 2 patients (0.4â¯%) had secundum ASD, and 2 patients (0.4â¯%) had both a PFO and ASD (1 of whom had undergone percutaneous repair of both lesions). Twelve patients (2.3â¯%) had a prior history of cerebrovascular accident either recorded on medical history or detected on neuropathological examination; however none of these patients had a PFO or ASD.CONCLUSIONS:
The combined rate of PFO and ASD in a cohort of 517 patients undergoing autopsy was 7.9â¯%. None of these patients had experienced a cerebrovascular accident. This rate of PFOs appears lower than earlier reports and raises the possibility that the relative risk of an associated stroke could be higher than previously estimated.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Acidente Vascular Cerebral
/
Forame Oval Patente
/
Comunicação Interatrial
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article