Your browser doesn't support javascript.
loading
Decreased rate of blood donors with high ABO antibody titers in Japan and the underlying factors: Comparisons between 2010 and 2021.
Mikame, Masamichi; Tsuno, Nelson Hirokazu; Miura, Yoshino; Kitazaki, Hideaki; Uchimura, Daisuke; Miyazaki, Toru; Miyagi, Toru; Onodera, Takayuki; Ohashi, Wataru; Kameda, Takahiro; Ohkawa, Ryunosuke; Kino, Shuichi; Muroi, Kazuo.
Afiliação
  • Mikame M; Japanese Red Cross Kanto-Koshinetsu Block Blood Center, 2-1-67, Tatsumi, Koto-ku, Tokyo, Japan; Japanese Red Cross Central Blood Institute, 2-1-67, Tatsumi, Koto-ku, Tokyo, Japan; Clinical Bioanalysis and Molecular Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental Uni
  • Tsuno NH; Japanese Red Cross Kanto-Koshinetsu Block Blood Center, 2-1-67, Tatsumi, Koto-ku, Tokyo, Japan; Japanese Red Cross Central Blood Institute, 2-1-67, Tatsumi, Koto-ku, Tokyo, Japan.
  • Miura Y; Japanese Red Cross Hokkaido Block Blood Center, 1-1-20, Niju-Yonken-Nijo, Nishi-ku, Sapporo-shi, Hokkaido, Japan.
  • Kitazaki H; Japanese Red Cross Hokkaido Block Blood Center, 1-1-20, Niju-Yonken-Nijo, Nishi-ku, Sapporo-shi, Hokkaido, Japan.
  • Uchimura D; Japanese Red Cross Hokkaido Block Blood Center, 1-1-20, Niju-Yonken-Nijo, Nishi-ku, Sapporo-shi, Hokkaido, Japan.
  • Miyazaki T; Japanese Red Cross Central Blood Institute, 2-1-67, Tatsumi, Koto-ku, Tokyo, Japan.
  • Miyagi T; Japanese Red Cross Kanto-Koshinetsu Block Blood Center, 2-1-67, Tatsumi, Koto-ku, Tokyo, Japan; Japanese Red Cross Central Blood Institute, 2-1-67, Tatsumi, Koto-ku, Tokyo, Japan.
  • Onodera T; Japanese Red Cross Kanto-Koshinetsu Block Blood Center, 2-1-67, Tatsumi, Koto-ku, Tokyo, Japan.
  • Ohashi W; Japanese Red Cross Hokkaido Block Blood Center, 1-1-20, Niju-Yonken-Nijo, Nishi-ku, Sapporo-shi, Hokkaido, Japan.
  • Kameda T; Clinical Bioanalysis and Molecular Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan; Department of Clinical Laboratory Science, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo, Japan.
  • Ohkawa R; Clinical Bioanalysis and Molecular Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan.
  • Kino S; Japanese Red Cross Hokkaido Block Blood Center, 1-1-20, Niju-Yonken-Nijo, Nishi-ku, Sapporo-shi, Hokkaido, Japan.
  • Muroi K; Japanese Red Cross Kanto-Koshinetsu Block Blood Center, 2-1-67, Tatsumi, Koto-ku, Tokyo, Japan.
Transfus Apher Sci ; 62(6): 103812, 2023 Dec.
Article em En | MEDLINE | ID: mdl-37734993
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Previously (2007), it was reported that ABO antibody titers in Japanese blood donors had decreased significantly compared to 20 years before. Here we evaluated whether further decrease of antibody titers had occurred in recent years, and the potential factors associated with changes in antibody titers. MATERIALS AND

METHODS:

Serum/plasma from random blood donors in 2010 and 2021 (2010 3369, 2021 5796 donors) was classified into low, middle, and high ABO antibody titers according to the reactivity of diluted serum/plasma (2.5-fold and 20-fold) by an automated microplate system. The rates of low/high titer in the two periods were compared. Logistic regression and age-gender-BMI subgroup analyses were conducted to identify the factors that contributed to changes in antibody titers.

RESULTS:

Compared to 2010, the rate of donors with high ABO antibody titers was　decreased in 2021 for both anti-A and anti-B (anti-A, 2010 23.8%, 2021 19.3%; anti-B, 2010 23.8%, 2021 16.4%). In logistic regression analysis, age was found to significantly affect both anti-A and anti-B antibody titers (anti-A, adjusted odds ratio 0.36, 95% CI 0.31-0.41; anti-B, 0.42, 0.37-0.47), and BMI (0.82, 0.73-0.92) and other time-related factors (0.79, 0.71-0.88) significantly affect anti-B antibody titers. Subgroup analysis revealed decreased rate of high anti-B titers in the higher age group in 2021.

CONCLUSION:

The rate of high ABO antibody titers, especially high anti-B titers, was significantly decreased in 2021, and our results suggested an association with aging and obesity of blood donors as well as other time-related factors.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doadores de Sangue / Anticorpos Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doadores de Sangue / Anticorpos Idioma: En Ano de publicação: 2023 Tipo de documento: Article