Design and Characterization of 1,3-Dihydro-2<i>H</i>-benzo[<i>d</i>]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors.

Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors.

Bamborough, Paul; Chung, Chun-Wa; Goodwin, Nicole C; Mitchell, Darren J; Neipp, Christopher E; Phillipou, Alex; Preston, Alex; Prinjha, Rab K; Soden, Peter E; Watson, Robert J; Demont, Emmanuel H.

Afiliação

Bamborough P; GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, U.K.
Chung CW; GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, U.K.
Goodwin NC; GlaxoSmithKline, Collegeville, Pennsylvania 19426, United States.
Mitchell DJ; GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, U.K.
Neipp CE; GlaxoSmithKline, Collegeville, Pennsylvania 19426, United States.
Phillipou A; GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, U.K.
Preston A; GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, U.K.
Prinjha RK; GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, U.K.
Soden PE; GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, U.K.
Watson RJ; GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, U.K.
Demont EH; GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, U.K.

ACS Med Chem Lett ; 14(9): 1231-1236, 2023 Sep 14.

Article em En | MEDLINE | ID: mdl-37736196

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article