Genetically determined thymic function affects strength and duration of immune response in COVID patients with pneumonia.
Sci Adv
; 9(38): eadh7969, 2023 09 22.
Article
em En
| MEDLINE
| ID: mdl-37738336
ABSTRACT
Thymic activation improves the outcome of COVID-19 patients with severe pneumonia. The rs2204985 genetic polymorphism within the TCRA-TCRD locus, which affects thymic output in healthy individuals, was found here to modify SARS-CoV-2-specific immunity and disease severity in COVID-19 patients with severe pneumonia. Forty patients with severe COVID-19 pneumonia were investigated. The GG genotype at the rs2204985 locus was associated, independently of age and sex, with stronger and long-lasting anti-SARS-CoV-2 helper and cytotoxic T cell responses 6 months after recovery. The GG genotype was also associated with less severe lung involvement, higher thymic production, and higher counts of blood naïve T lymphocytes, including recent thymic emigrants, and a larger population of activated stem cell memory CD4+ T cells. Overall, GG patients developed a more robust and sustained immunity to SARS-CoV-2. Polymorphism at rs2204985 locus should be considered as an additional predictive marker of anti-SARS-CoV-2 immune response.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pneumonia
/
COVID-19
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article