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Disentangling the nonmetabolic roles of metabolites: lactate as a case study.
Mohammad Nezhady, Mohammad Ali; Bajon, Emmanuel; Chemtob, Sylvain.
Afiliação
  • Mohammad Nezhady MA; Program in Molecular Biology, Faculty of Medicine, University of Montreal, Montreal, QC, Canada; Research Center of Sainte-Justine University Hospital, Montreal, QC H3T 1C5, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada. Electronic address: ma.mohammad.nezhady@gmail.com.
  • Bajon E; Research Center of Sainte-Justine University Hospital, Montreal, QC H3T 1C5, Canada.
  • Chemtob S; Program in Molecular Biology, Faculty of Medicine, University of Montreal, Montreal, QC, Canada; Research Center of Sainte-Justine University Hospital, Montreal, QC H3T 1C5, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.
Trends Endocrinol Metab ; 34(12): 786-788, 2023 12.
Article em En | MEDLINE | ID: mdl-37739879
Many metabolites possess covalent and noncovalent signaling functions. However, ongoing research considers them mostly as ligands, neglecting their potential involvement in post-translational modifications. In this forum article, we discuss the dual signaling functions of metabolites, using lactate as a case study, and advocate for the use of multiple complementary techniques to disentangle their functions.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Ácido Láctico Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Ácido Láctico Idioma: En Ano de publicação: 2023 Tipo de documento: Article