Toxoplasma gondii Induces Pyroptosis in Human Placental Trophoblast and Amniotic Cells by Inducing ROS Production and Activation of Cathepsin B and NLRP1/NLRP3/NLRC4/AIM2 Inflammasome.

Quan, Juan-Hua; Gao, Fei Fei; Ma, Tian-Zhong; Ye, Wei; Gao, Xiang; Deng, Ming-Zhu; Yin, Lan-Lan; Choi, In-Wook; Yuk, Jae-Min; Cha, Guang-Ho; Lee, Young-Ha; Chu, Jia-Qi

Toxoplasma gondii Induces Pyroptosis in Human Placental Trophoblast and Amniotic Cells by Inducing ROS Production and Activation of Cathepsin B and NLRP1/NLRP3/NLRC4/AIM2 Inflammasome.

Quan, Juan-Hua; Gao, Fei Fei; Ma, Tian-Zhong; Ye, Wei; Gao, Xiang; Deng, Ming-Zhu; Yin, Lan-Lan; Choi, In-Wook; Yuk, Jae-Min; Cha, Guang-Ho; Lee, Young-Ha; Chu, Jia-Qi.

Afiliação

Quan JH; Department of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, People's Republic of China.
Gao FF; Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, People's Republic of China.
Ma TZ; Reproductive Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, People's Republic of China.
Ye W; Department of Obstetrics and Gynecology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, People's Republic of China.
Gao X; Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, People's Republic of China.
Deng MZ; Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, People's Republic of China.
Yin LL; Reproductive Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, People's Republic of China.
Choi IW; Department of Infection Biology and Department of Medical Science, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Yuk JM; Department of Infection Biology and Department of Medical Science, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Cha GH; Department of Infection Biology and Department of Medical Science, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Lee YH; Department of Infection Biology and Department of Medical Science, Chungnam National University College of Medicine, Daejeon, Republic of Korea. Electronic address: yhalee@cnu.ac.kr.
Chu JQ; Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, People's Republic of China. Electronic address: chujiaqi@gdmu.edu.cn.

Am J Pathol ; 193(12): 2047-2065, 2023 12.

Article em En | MEDLINE | ID: mdl-37741453

Assuntos

Inflamassomos; Toxoplasma; Camundongos; Animais; Humanos; Feminino; Gravidez; Inflamassomos/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Piroptose; Trofoblastos/metabolismo; Catepsina B/metabolismo; Catepsina B/farmacologia; Placenta/metabolismo; RNA Interferente Pequeno; Caspases/metabolismo; Proteínas de Ligação ao Cálcio/metabolismo; Proteínas Adaptadoras de Sinalização CARD/metabolismo; Proteínas NLR/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Toxoplasma / Inflamassomos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Toxoplasma / Inflamassomos Idioma: En Ano de publicação: 2023 Tipo de documento: Article