STING negatively regulates antifungal immunity.

Gu, Yebo; Jia, Xin-Ming.

Afiliação

Gu Y; Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
Jia XM; Clinical Medicine Scientific and Technical Innovation Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China; Key Laboratory of Pathogen-Host Interactions of the Ministry of Education of China, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200092, China. Electronic address: jiaxm@tongji.edu.cn.

Trends Microbiol ; 31(11): 1090-1092, 2023 Nov.

Article em En | MEDLINE | ID: mdl-37741789

ABSTRACT

During viral infections, stimulator of interferon genes (STING) exerts a positive protective immune response. Chen et al. now shed light on the distinct role of STING in fungal infections. STING translocates to the phagosome to negatively regulate the immune response against Candida albicans infection through the inhibition of Src-involved Syk phosphorylation.

Palavras-chave

STING; antifungal immunity; negative regulation

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article