A Comparison of the Enamel Remineralisation Potential of Self-Assembling Peptides.
Int Dent J
; 74(2): 187-194, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-37743135
ABSTRACT
BACKGROUND:
The aim of this research was to compare the efficacy of the remineralising potential of self-assembling peptides (SAPs) Curodont Repair (P11-4), P26, and leucine-rich amelogenin peptides (LRAP) with the standard 5% NaF varnish (Duraphat) on early enamel caries lesions (EECLs).METHODS:
A demineralising solution (DS) was used to create artificial EECLs in human dental enamel specimens, which were randomly allocated to treatment groups P11-4; P26 solution; LRAP solution; 5% NaF varnish; and deionised water (DIW). Each specimen was subjected to 8 days of pH cycling. Specimens from each test group were subjected to microcomputed tomography (micro-CT) and nanomechanical testing to assess mineral density (MD), hardness (H), and elastic modulus (EM) properties of sound, demineralised, and treated enamel.RESULTS:
The mean MD percentage gain was highest in the P26 and P11-4 groups, followed by the LRAP, 5% NaF varnish, and DIW groups. There were statistically significant differences amongst groups. In the outer layer of EECLs, the EM and H were highest in P26 and P11-4 groups, followed by the LRAP and 5% NaF varnish. In the inner layer of EECLs, the EM and H were highest in P11-4 and P26 groups, indicative of enhanced penetration and remineralisation of the deeper parts of the artificial EECLs.CONCLUSIONS:
P26 and P11-4 SAPs are more effective than 5% NaF varnish in remineralising the depth of EECLs.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Cárie Dentária
/
Esmalte Dentário
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article