Homeostatic role of B-1 cells in tissue immunity.
Front Immunol
; 14: 1106294, 2023.
Article
em En
| MEDLINE
| ID: mdl-37744333
ABSTRACT
To date, studies of tissue-resident immunity have mainly focused on innate immune cells and T cells, with limited data on B cells. B-1 B cells are a unique subset of B cells with innate-like properties, enriched in murine pleural and peritoneal cavities and distinct from conventional B-2 cells in their ontogeny, phenotype and function. Here we discuss how B-1 cells represent exemplar tissue-resident immune cells, summarizing the evidence for their long-term persistence & self-renewal within tissues, differential transcriptional programming shaped by organ-specific environmental cues, as well as their tissue-homeostatic functions. Finally, we review the emerging data supporting the presence and homeostatic role of B-1 cells across non-lymphoid organs (NLOs) both in mouse and human.
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Base de dados:
MEDLINE
Assunto principal:
Subpopulações de Linfócitos B
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article