Extraction of characteristic serum microRNAs and prediction of target genes in IgG4-related dacryoadenitis and sialadenitis.
Mod Rheumatol
; 34(3): 632-638, 2024 Mar 28.
Article
em En
| MEDLINE
| ID: mdl-37747366
ABSTRACT
OBJECTIVES:
To identify the specific microRNAs (miRNAs) in IgG4-related dacryoadenitis and sialadenitis (IgG4-DS) and predict the targeted genes.METHODS:
miRNAs in the serum of nine patients with IgG4-DS, three patients with primary Sjögren's syndrome, and three healthy controls were analysed using the human miRNA chip, and miRNAs that exhibited significant fluctuation in expression in IgG4-DS patients were extracted. The respective target genes were predicted using an existing database, and expression of the target genes was evaluated in actual submandibular gland tissues affected by IgG4-DS.RESULTS:
Serum miR-125a-3p and miR-125b-1-3p levels were elevated in IgG4-DS. Six candidate target genes (glypican 4, forkhead box C1, protein tyrosine phosphatase non-receptor type 3, hydroxycarboxylic acid receptor 1, major facilitator superfamily domain containing 11, and tumour-associated calcium signal transducer 2) were downregulated in the affected submandibular gland tissue.CONCLUSION:
Overexpression of miR-125a-3p and miR-125b-1-3p is a hallmark of IgG4-DS. These miRNAs appear to be involved in the pathogenesis of IgG4-DS.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sialadenite
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Síndrome de Sjogren
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Dacriocistite
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MicroRNAs
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article