Electron microscopy mapping of the DNA-binding sites of monomeric, dimeric, and multimeric KSHV RTA protein.
J Virol
; 97(10): e0063723, 2023 10 31.
Article
em En
| MEDLINE
| ID: mdl-37750723
ABSTRACT
IMPORTANCE Kaposi's sarcoma-associated herpesvirus (KSHV) is a human herpesvirus associated with several human cancers, typically in patients with compromised immune systems. Herpesviruses establish lifelong infections in hosts in part due to the two phases of infection the dormant and active phases. Effective antiviral treatments to prevent the production of new viruses are needed to treat KSHV. A detailed microscopy-based investigation of the molecular interactions between viral protein and viral DNA revealed how protein-protein interactions play a role in DNA-binding specificity. This analysis will lead to a more in-depth understanding of KSHV DNA replication and serve as the basis for anti-viral therapies that disrupt and prevent the protein-DNA interactions, thereby decreasing spread to new hosts.
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Base de dados:
MEDLINE
Assunto principal:
DNA Viral
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Microscopia Eletrônica
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Transativadores
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Herpesvirus Humano 8
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Multimerização Proteica
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article