Molecular characterization of the 2022 Sudan virus disease outbreak in Uganda.
J Virol
; 97(10): e0059023, 2023 10 31.
Article
em En
| MEDLINE
| ID: mdl-37750724
ABSTRACT
IMPORTANCE Ebola disease (EBOD) is a public health threat with a high case fatality rate. Most EBOD outbreaks have occurred in remote locations, but the 2013-2016 Western Africa outbreak demonstrated how devastating EBOD can be when it reaches an urban population. Here, the 2022 Sudan virus disease (SVD) outbreak in Mubende District, Uganda, is summarized, and the genetic relatedness of the new variant is evaluated. The Mubende variant exhibited 96% amino acid similarity with historic SUDV sequences from the 1970s and a high degree of conservation throughout the outbreak, which was important for ongoing diagnostics and highly promising for future therapy development. Genetic differences between viruses identified during the Mubende SVD outbreak were linked with epidemiological data to better interpret viral spread and contact tracing chains. This methodology should be used to better integrate discrete epidemiological and sequence data for future viral outbreaks.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Variação Genética
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Surtos de Doenças
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Doença pelo Vírus Ebola
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Ebolavirus
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article