A ratiometric fluorescent probe for rapid and specific detection of hypochlorite.
Luminescence
; 39(1): e4600, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-37752625
ABSTRACT
Hypochlorite (ClO- ), as a kind of essential reactive oxygen species, plays a crucial role in vitro and in vivo. Here, a ratiometric fluorescent probe (TPAM) was designed and constructed for sensing ClO- based on substituted triphenylamine and malononitrile, which exhibited obvious colour transfer from orange to colourless under daylight accompanied by noticeable fluorescence change from red to green in response to ClO- . TPAM could effectively monitor ClO- with the merits of fast response, excellent selectivity, high sensitivity and a low detection limit of 0.1014 µM. 1 H NMR, mass spectra and theoretical calculations proved that ClO- caused the oxidation of the carbon-carbon double bond in TPAM, resulting in compound 1 and marked changes in colour and fluorescence. In addition, TPAM was utilized for imaging ClO- in living cells successfully with good photostability and biocompatibility.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ácido Hipocloroso
/
Corantes Fluorescentes
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article