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Depletion of dexamethasone in cattle: Food safety study in dairy and beef cattle.
Chicoine, Al; Renaud, David L; Enouri, Saad S; Dowling, Patricia M; Gu, Yu; Johnson, Ron J.
Afiliação
  • Chicoine A; Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
  • Renaud DL; Department of Population Medicine, University of Guelph, Guelph, Ontario, Canada.
  • Enouri SS; Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada.
  • Dowling PM; Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
  • Gu Y; Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada.
  • Johnson RJ; Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada.
J Vet Pharmacol Ther ; 47(2): 80-86, 2024 Mar.
Article em En | MEDLINE | ID: mdl-37755169
ABSTRACT
Dexamethasone is approved for cattle in Canada for several conditions, but no withdrawal times are currently provided on the approved labels. Recently, the list of Maximum Residues Limits for Veterinary Drugs in Foods in Canada was amended to include dexamethasone. The objectives of this study were to determine the residue depletion profile of dexamethasone after an extra-label dosage regimen in milk of healthy lactating dairy cattle (n = 18) and in edible tissues of healthy beef cattle (n = 16) and to suggest withdrawal intervals. Dexamethasone was administered intramuscularly at 0.05 mg/kg daily for 3 days. Milk samples were collected prior to treatment and every 12 h up to 96 h post-dose. Muscle, liver, kidney, and peri-renal fat tissues were collected from beef cattle at 3, 7, 11, or 15 days post-dose. Dexamethasone analysis was performed by liquid chromatography/mass spectrophotometry. Dexamethasone residues were detected in milk samples up to 36 h. Muscle and fat had no detectable dexamethasone residues while kidney and liver had detectable residues only on day 3 post-dose. A withdrawal interval of 48 h for milk in Canadian dairy cattle and 7 days for meat in Canadian beef cattle are suggested for the dexamethasone treatment regimen most commonly requested to CgFARAD™.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lactação / Resíduos de Drogas Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lactação / Resíduos de Drogas Idioma: En Ano de publicação: 2024 Tipo de documento: Article