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Antifungal and Antiaflatoxigenic Activities of Massoia Essential Oil and C10 Massoia Lactone against Aflatoxin-Producing Aspergillus flavus.
Lee, Yubin; Park, Soo Jean; Kim, Kyeongnam; Kim, Tae-Oh; Lee, Sung-Eun.
Afiliação
  • Lee Y; Department of Integrative Biology, Kyungpook National University, Daegu 41566, Republic of Korea.
  • Park SJ; Applied BioSciences, Macquarie University, North Ryde, NSW 2109, Australia.
  • Kim K; Institute of Quality and Safety Evaluation of Agricultural Products, Kyungpook National University, Daegu 41566, Republic of Korea.
  • Kim TO; Department of Environmental Engineering, Kumoh National Institute of Technology, Gumi 39177, Republic of Korea.
  • Lee SE; Department of Integrative Biology, Kyungpook National University, Daegu 41566, Republic of Korea.
Toxins (Basel) ; 15(9)2023 09 16.
Article em En | MEDLINE | ID: mdl-37755997
ABSTRACT
Fungal infection and mycotoxin contamination are major hazards to the safe storage and distribution of foods and feeds consumed by humans and livestock. This study investigated the antifungal and antiaflatoxigenic activities of massoia essential oil (MEO) and its major constituent, C10 massoia lactone (C10), against aflatoxin B (AFB)-producing Aspergillus flavus ATCC 22546. Their antifungal activities were evaluated using a disc diffusion assay, agar dilution method, and a mycelial growth inhibition assay with the AFB analysis using liquid chromatography triple quadrupole mass spectrometry. MEO and C10 exhibited similar antifungal and antiaflatoxigenic activities against A. flavus. C10 was a primary constituent in MEO and represented up to 45.1% of total peak areas analyzed by gas chromatography-mass spectrometry, indicating that C10 is a major compound contributing to the antifungal and antiaflatoxigenic activities of MEO. Interestingly, these two materials increased AFB production in A. flavus by upregulating the expression of most genes related to AFB biosynthesis by 3- to 60-fold. Overall, MEO and C10 could be suitable candidates as natural preservatives to control fungal infection and mycotoxin contamination in foods and feeds as Generally Recognized As Safe (GRAS) in the Flavor and Extract Manufacturers Association of the United States (FEMA), and MEO is a more suitable substance than C10 because of its wider range of uses and higher allowed concentration than C10.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aflatoxinas / Micotoxinas Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aflatoxinas / Micotoxinas Idioma: En Ano de publicação: 2023 Tipo de documento: Article